Lactic Acidosis as Presenting Symptom of Thiamine Deficiency in Children with Hematologic Malignancy
نویسندگان
چکیده
منابع مشابه
Type B lactic acidosis secondary to thiamine deficiency in a child with malignancy.
Type B lactic acidosis is an underrecognized clinical entity that must be distinguished from type A (hypoxic) lactic acidosis. We present the case of a 4-year-old boy with medulloblastoma who presented with lactic acidosis in the setting of septic shock. His hyperlactatemia persisted to high levels even after his hemodynamic status improved. After administration of intravenous thiamine, his lac...
متن کاملReversible lactic acidosis in a newborn with thiamine transporter-2 deficiency.
Thiamine transporter-2 deficiency is a recessive disease caused by mutations in the SLC19A3 gene. Patients manifest acute episodes of encephalopathy; symmetric lesions in the cortex, basal ganglia, thalami or periaqueductal gray matter, and a dramatic response to biotin or thiamine. We report a 30-day-old patient with mutations in the SLC19A3 gene who presented with acute encephalopathy and inc...
متن کاملReversible Lactic Acidosis in a Newborn With Thiamine Transporter-2 Deficiency abstract
Thiamine transporter-2 deficiency is a recessive disease caused by mutations in the SLC19A3 gene. Patients manifest acute episodes of encephalopathy; symmetric lesions in the cortex, basal ganglia, thalami or periaqueductal gray matter, and a dramatic response to biotin or thiamine. We report a 30-day-old patient with mutations in the SLC19A3 gene who presented with acute encephalopathy and inc...
متن کاملThiamine Deficiency Presenting as Intraventricular Hemorrhage.
Case Description A 48-year-old man with hypertension, coronary artery disease, and obesity presented with a 6-week history of nausea, vomiting, decreased oral intake with 40-pound weight loss, and lethargy. Laboratory results were significant for low platelet count of 71 000 per mm, slight elevation of prothrombin time/partial thromboplastin time and international normalized ratio acute kidney ...
متن کاملThiamine Deficiency Leading to Refractory Lactic Acidosis in a Pediatric Patient
Thiamine plays a critical role in energy metabolism. Critically ill children and adults may develop thiamine deficiency with ultimately increased mortality due to potentially irreversible consequences of severe type B lactic acidosis. We report a case of an unvaccinated term neonate with malignant pertussis requiring extracorporeal membrane oxygenation and continuous renal replacement therapy, ...
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ژورنال
عنوان ژورنال: Journal of Pediatric Intensive Care
سال: 2016
ISSN: 2146-4618,2146-4626
DOI: 10.1055/s-0036-1587325